Drug eruption
☆ Emiphumeleni ka-2022 ye-Stiftung Warentest evela eJalimane, ukwaneliseka kwabathengi nge-ModelDerm bekungaphansi kancane kunokuxhumana okukhokhelwayo kwe-telemedicine.
I- Drug eruption ibonakala ngokuthinta umzimba wonke.
References
Ukusabela kwesikhumba okubangelwa imithi, okwaziwa ngokuthi ukuqhuma kwezidakamizwa, ngezinye izikhathi kungaba kubi kakhulu. Lokhu kusabela okunzima, okubizwa ngokuthi severe cutaneous adverse drug reactions (SCARs) , kuthathwa njengokubeka impilo engcupheni. Zihlanganisa izimo ezifana ne- Stevens-Johnson syndrome (SJS) , toxic epidermal necrolysis (TEN) , acute generalized exanthematous pustulosis (AGEP) , and drug reaction with eosinophilia and systemic symptoms (DRESS) . Nakuba okuthi SCARs kuyivelakancane, cishe u-2% weziguli ezilaliswe esibhedlela ziyabathola.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Owesifazane oneminyaka engu-31 ubudala uvakashele umnyango wezifo zesikhumba enebala elibomvu elingenabuhlungu phezulu onyaweni lwakhe lwesokudla. Uphuze umthamo owodwa we-doxycycline (100 mg) ngosuku olwedlule, elandela ukwelashwa nge-picosecond laser yezibazi zezinduna. Ngonyaka odlule, wabhekana nenkinga efanayo endaweni efanayo ngemva kokuthatha umthamo ofanayo we-doxycycline yokwelashwa kwe-post-laser. Akanawo umlando obalulekile wezempilo futhi azikho ezinye izimpawu, njengomkhuhlane, endaweni noma kuwo wonke umzimba wakhe.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
I- Stevens-Johnson syndrome (SJS) kanye ne- toxic epidermal necrolysis (TEN) ziyizinhlobo ezimbili zokusabela kwesikhumba okubucayi, okuhlukile kwezinye izimo zesikhumba njenge-erythema multiforme enkulu kanye ne-staphylococcal scalded skin syndrome, kanye nokusabela kwezidakamizwa. I- SJS/TEN ukusabela okungajwayelekile futhi okunzima okubangela ukulimala kwesikhumba nolwelwesi lwamafinyila, okuvamise ukuba nezimpawu zesistimu. Ezimweni ezingaphezu kuka-80%, imithi iyimbangela.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Ukuqhuma kwezidakamizwa kutholakala ikakhulukazi emlandweni wezokwelapha kanye nokuhlolwa komtholampilo. I-biopsy yesikhumba, ukuhlolwa kwegazi noma ukuhlolwa kwe-immunological nakho kungaba wusizo.
Izibonelo zezidakamizwa ezivamile ezibangela ukuqhuma ama-antibiotics nezinye izidakamizwa ezilwa namagciwane, izidakamizwa ze-sulfa, izidakamizwa ezingezona ukuvuvukala (ama-NSAID), ama-chemotherapy agents for malignancies, anticonvulsants nezidakamizwa ze-psychotropic.
○ Ukuxilongwa Nokwelashwa
Uma unomkhuhlane (ukushisa komzimba okwenyukayo), kufanele ufune usizo lwezokwelapha ngokushesha ngangokunokwenzeka. Umuthi okusolwayo kufanele uyekwe (isb. ama-antibiotic, izidakamizwa ezingezona ukuvuvukala). Ngaphambi kokuvakashela esibhedlela, ama-antihistamine omlomo afana ne-cetirizine noma i-loratadine angasiza ekulume nokuqubuka.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Ukuhlolwa kwegazi (CBC, LFT, eosinophil count)
Ama-Oral steroids nama-antihistamine anencwadi kadokotela